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NEWProduct Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
Tesamorelin
Product information
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Product description
Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that stimulates the production and release of endogenous growth hormone (GH) from the anterior pituitary gland. This peptide has been extensively researched for its potential to improve metabolic health, reduce visceral adipose tissue (VAT), and enhance cognitive function in various populations, including those with HIV-associated lipodystrophy and age-related cognitive decline.
Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
- Characteristics
- How does Tesamorelin work?
- Research
- Side Effects
- Summary
- Certificate of Analysis (COA)
- References
Table of Contents
- Characteristics
- How does Tesamorelin work?
- Research
- Side Effects
- Summary
- Certificate of Analysis (COA)
- References
Characteristics
| NAME | ROLE |
|---|---|
Molecular Formula | C221H366N72O67S |
CAS Number | 218949-48-5 |
Molar Mass | 5135.9 g/mol |
Amino Acid Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 |
Synonyms | TH9507, Egrifta, Lipodystrophy Drug |
Solubility | Water-soluble |
Organoleptic Profile | White to off-white powder |
Composition | Tesamorelin acetate |
How does Tesamorelin work?
Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog that has been the subject of extensive research in the field of endocrinology and metabolism. This peptide's primary mechanism of action involves binding to and activating the growth hormone-releasing hormone receptor (GHRHR) in the anterior pituitary gland. This activation stimulates the synthesis and pulsatile release of endogenous growth hormone (GH), which in turn promotes the production of insulin-like growth factor-1 (IGF-1) in the liver and other tissues.
Research
Visceral Adipose Tissue (VAT) Reduction: Clinical studies have shown that tesamorelin can significantly reduce VAT in individuals with HIV-associated lipodystrophy and in obese individuals without HIV. This reduction in VAT has been associated with improvements in metabolic health markers.
Insulin Sensitivity: Investigations have indicated that tesamorelin treatment may improve insulin sensitivity in certain populations, including individuals with HIV-associated lipodystrophy and obese individuals without HIV.
Cognitive Function: Some studies have explored tesamorelin's potential effects on cognitive function in older adults with mild cognitive impairment (MCI). Preliminary findings suggest possible improvements in executive function, attention, and memory.
Muscle Mass and Strength: Research has indicated that tesamorelin may increase muscle mass and strength in older adults and individuals with HIV-associated lipodystrophy.
Bone Health: Studies have observed increases in bone mineral density (BMD) in individuals with HIV-associated lipodystrophy following tesamorelin treatment.
Side Effects
Injection site reactions
Edema
Arthralgia
Hypersensitivity reactions
Less frequent side effects may include headache, dizziness, and gastrointestinal disturbances. In rare cases, tesamorelin may cause carpal tunnel syndrome or increase the risk of malignancy.
Summary
Tesamorelin is a potent growth hormone-releasing hormone (GHRH) analog that has been extensively researched for its potential to improve metabolic health, reduce visceral adipose tissue (VAT), and enhance cognitive function in various populations. By stimulating the production and release of endogenous growth hormone (GH) from the anterior pituitary gland, tesamorelin promotes the production of insulin-like growth factor-1 (IGF-1), leading to numerous metabolic and cognitive benefits. Studies have demonstrated that tesamorelin significantly reduces VAT, improves insulin sensitivity, enhances cognitive function, increases muscle mass and strength, and promotes bone health in individuals with HIV-associated lipodystrophy, obesity, and age-related cognitive decline. As a research peptide, tesamorelin holds promise for further investigating the complex interplay between growth hormone, metabolism, and cognitive function, potentially leading to the development of novel therapeutic strategies for various metabolic and cognitive disorders.
References
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