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KPV

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$85.99

Product description

KPV (Lysine-Proline-Valine) is a synthetic tripeptide fragment derived from the C-terminus of alpha-melanocyte-stimulating hormone (α-MSH). It has been studied in laboratory settings for its role in immune signaling pathways and cellular communication.

Research in non-human models has explored KPV’s interaction with immune cells and signaling proteins in environments associated with inflammation and oxidative stress. These studies are preliminary and intended to advance understanding of basic biological mechanisms. Requires reconstitution before use.

Size:

10mg

Research Spray Kit$39.99

KPV (10mg)

$85.99

Research Spray Kit$39.99

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This product is not approved for human or animal consumption.Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.

This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.

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Table of Contents

  1. Characteristics
  2. How does KPV work?
  3. Research
  4. Side Effects
  5. Summary
  6. References
  7. Certificate of Analysis (COA)
  8. Resource

Characteristics

Molecular Formula

C16H29N3O4

CAS-number

67727-97-3

Molar Mass

327.42 g/mol

Chemical Formula

Lys-Pro-Val

Amino Acid Sequence

Lys-Pro-Val

Synonyms

KPV tripeptide, α-MSH(11-13), KPV peptide

Solubility

Water-soluble (≥1 mg/mL)

Organoleptic Profile

White to off-white powder

Composition

Lyophilized powder - requires reconstitution

How does KPV work?

 KPV is a tripeptide derived from α-melanocyte-stimulating hormone (α-MSH) that has been studied in scientific settings for its role in regulating inflammatory responses and immune system activity in non-human models.

Research

Research involving mammalian models has explored how KPV may influence certain biological processes: 1.Cytokine Response-Laboratory studies suggest KPV may affect the production of signaling molecules involved in inflammation. 2.Immune Modulation-Investigations have observed KPV's interaction with immune cells such as macrophages and T cells. 3.Melanocortin Pathways-KPV has been shown to activate specific receptors in controlled experiments, contributing to research into inflammation regulation.

Preclinical studies have examined KPV in the context of: Digestive tract balance, joint and connective tissue function, skin integrity and recovery, neurological research models, cellular regeneration processes.

Side Effects

While preclinical studies in mammalian models have not reported significant adverse effects, it is important to note that comprehensive safety data in mammals, particularly in long-term use scenarios, is still limited. Further research is needed to fully establish the safety profile of KPV.

Summary

KPV is a research peptide of scientific interest due to its observed activity in laboratory models, particularly those examining inflammatory and immune response mechanisms. While it has been evaluated in preclinical settings, KPV has not been reviewed or approved by regulatory bodies for medical or dietary use.

Disclaimer: This material is provided for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. This product is intended strictly for laboratory research use and not for human or veterinary consumption.

References

  1. Zhao Y, Xue P, Lin G, Tong M, Yang J, Zhang Y, Ran K, Zhuge D, Yao Q, Xu H. A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon. Acta Biomater. 2022 Apr 15;143:233-252. doi: 10.1016/j.actbio.2022.02.039. Epub 2022 Mar 1. PMID: 35245681.

  2. Shao W, Chen R, Lin G, Ran K, Zhang Y, Yang J, Pan H, Shangguan J, Zhao Y, Xu H. In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis. Biomater Sci. 2021 Dec 21;10(1):227-242. doi: 10.1039/d1bm01466h. PMID: 34846053.

  3. Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804.

  4. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008 Jan;134(1):166-78. doi: 10.1053/j.gastro.2007.10.026. Epub 2007 Oct 17. PMID: 18061177; PMCID: PMC2431115.

  5. Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008 Mar;14(3):324-31. doi: 10.1002/ibd.20334. PMID: 18092346.

  6. Hiltz ME, Lipton JM. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. FASEB J. 1989 Sep;3(11):2282-4. PMID: 2550304.

  7. Pawar K, Kolli CS, Rangari VK, Babu RJ. Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin. J Pharm Sci. 2017 Jul;106(7):1814-1820. doi: 10.1016/j.xphs.2017.03.017. Epub 2017 Mar 24. PMID: 28343991.

  8. Colombo G, Gatti S, Sordi A, Turcatti F, Carlin A, Rossi C, Lonati C, Catania A. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Shock. 2007 Mar;27(3):326-33. doi: 10.1097/01.shk.0000239764.80033.7e. PMID: 17304115.

  9. Ichiyama T, Sato S, Okada K, Catania A, Lipton JM. The neuroimmunomodulatory peptide alpha-MSH. Ann N Y Acad Sci. 2000;917:221-6. doi: 10.1111/j.1749-6632.2000.tb05386.x. PMID: 11268347.

Resource

All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration....
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