Nasal Spray Add-on Kit

Kit Contents:

• 1 Amber glass nasal spray bottle (10ml capacity)

• Precision nasal applicator with metered dosing (0.12ml per spray)

• Nasal spray reconstitution solution (7ml)

• Note: Power Peptides peptide vials sold separately. Syringes and alcohol wipes required for reconstitution are not included in this kit.

Store Reconstitution Solution at room temperature (15-30°C) in a dry place out of direct sunlight. After reconstitution with peptide, store nasal spray bottle in the refrigerator and use within 30 days of reconstitution.

The Nasal Spray Add-on Kit provides researchers with the tools necessary to explore nasal administration pathways for peptide research. The specialized bottle and precision applicator allow for controlled, metered delivery of reconstituted peptides to nasal mucosa. The nasal route offers several unique research advantages compared to other administration methods:

• The nasal cavity contains a highly vascularized mucosa with direct access to systemic circulation

• This administration pathway potentially bypasses first-pass hepatic metabolism

• Allows for investigation of comparative bioavailability across different delivery methods

• Enables research into peptide stability in alternative administration environments

When a peptide is reconstituted using the provided solution and transferred to the nasal spray bottle, researchers can conduct experiments exploring absorption kinetics and bioavailability through nasal administration pathways.

Advantages Over Oral Delivery

• Nasal delivery bypasses the harsh stomach environment and liver metabolism. This helps preserve peptide integrity and may improve research outcomes on bioavailability.

Benefits Compared to Injections

• Unlike subcutaneous or intramuscular injections, nasal administration is non-invasive. This allows researchers to study different absorption patterns without tissue disruption.

Rapid Absorption Potential

• The nasal cavity's rich blood supply and large surface area supports fast absorption into circulation. This creates opportunities to study immediate effects in research models.

Unique Brain Pathway Access

• The proximity to the olfactory region enables research on potential direct nose-to-brain pathways. This mechanism is unavailable with other delivery methods.

Enhanced Research Flexibility

• Comparing multiple administration routes provides valuable insights for peptide research. Nasal delivery adds another dimension to comprehensive pharmacokinetic studies.

Stability in Different Environments

• Researchers can explore how peptides perform in the nasal mucosa compared to other tissues. This helps identify optimal delivery strategies for various compounds.