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Tirzepatide

Product information

$199.99

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Tirzepatide (10mg)

$ 199.99

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Product description

Tirzepatide is a novel, synthetic, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist under investigation for its potential in treating type 2 diabetes and obesity. By combining the actions of GIP and GLP-1, Tirzepatide aims to improve glycemic control and promote weight loss more effectively than existing monotherapies. This dual agonist approach enhances insulin secretion, suppresses glucagon levels, and slows gastric emptying, contributing to improved metabolic outcomes.

Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.

Table of Contents

  1. Characteristics
  2. How does Tirzepatide work?
  3. Research
  4. Side Effects
  5. Summary
  6. Certificate of Analysis (COA)
  7. References

Characteristics

Molecular Formula

C225H348N60O68

CAS Number

2023788-19-2

Molar Mass

5047.61 g/mol

Amino Acid Sequence

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly

Synonyms

LY3298176

Solubility

Water-soluble

Organoleptic Profile

White to off-white powder

Composition

Synthetic, lyophilized powder

How does Tirzepatide work?

Tirzepatide is a novel synthetic peptide that acts as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Its unique structure allows it to activate both GIP and GLP-1 receptors, which are found in various tissues throughout the body.

Research

Glycemic Control

Multiple clinical trials have investigated Tirzepatide's effects on glycemic control in individuals with type 2 diabetes:

  • Significant reductions in HbA1c levels compared to placebo and active comparators

  • Improvements in fasting and postprandial glucose levels

Weight Management

Studies have examined Tirzepatide's impact on body weight:

  • Substantial weight loss observed in individuals with obesity or overweight

  • Weight loss effects appear to be dose-dependent

Cardiovascular Effects

Research has explored potential cardiovascular impacts:

  • Improvements in lipid profiles, including reductions in triglycerides and LDL cholesterol

  • Modest reductions in blood pressure observed in some studies

Renal Function

Limited data suggest potential renal effects:

  • Reductions in albuminuria reported in some trials

  • Long-term effects on kidney function require further investigation

Side Effects

The most common side effects reported in clinical trials include:

  • Gastrointestinal symptoms (nausea, vomiting, diarrhea)

  • Injection site reactions (pain, redness, itching)

  • Hypoglycemia (low blood sugar) when used with insulin or sulfonylureas

  • Increased heart rate

  • Allergic reactions (rare)

Summary

Tirzepatide represents a novel approach in the treatment of type 2 diabetes and obesity, leveraging dual activation of GIP and GLP-1 receptors. Clinical research has demonstrated its efficacy in improving glycemic control and promoting weight loss. While showing promise, long-term studies are needed to fully elucidate its effects on cardiovascular and renal outcomes.

References

  1. Gentilella R, Pechtner V, Corcos A, Consoli A. Glucagon-like peptide-1 receptor agonists in type 2 diabetes treatment: are they all the same?. Diabetes Metab Res Rev. 2019

  2. Samms RJ, Coghlan MP, Sloop KW. How May GIP Enhance the Therapeutic Efficacy of GLP-1?. Trends Endocrinol Metab. 2020

  3. Coskun T, Sloop KW, Loghin C, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. Mol Metab. 2018

  4. Frias JP, Davies MJ, Rosenstock J, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021

  5. Rosenstock J, Wysham C, Frías JP, et al. Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. Lancet. 2021

  6. Del Prato S, Kahn SE, Pavo I, et al. Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet. 2021

  7. Dahl D, Onishi Y, Norwood P, et al. Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial. JAMA. 2022

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