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IN-VITRO RESEARCH ONLY — NOT FOR HUMAN USE
PT-141
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$38.49
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$54.99
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PT-141 research compound, also known as Bremelanotide. Supplied as a lyophilized blend for laboratory research.
This product is purity-tested for compound identity and is intended for in vitro experimentation, analytical reference, or scientific characterization studies.
For laboratory research use only. Not for human or veterinary use.
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PT-141 (10mg)
$38.49
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Reconstitution Solution
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IN-VITRO RESEARCH ONLY — NOT FOR HUMAN USE
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PT-141
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Characteristics
Molecular Formula | C50H68N14O10 |
CAS Number | 189691-06-3 |
Molar Mass | 1025.2 g/mol |
Amino Acid Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
Synonyms | Bremelanotide, PT-141, PT141, PT 141 |
Solubility | Water-soluble |
Organoleptic Profile | White to off-white powder |
Composition | Lyophilized powder - requires reconstitution |
Form | Lyophilized powder |
Storage | Store at -20 °C, dry and protected from light. Short-term storage at 2–8 °C is acceptable for up to 4 weeks. |
How does PT-141 work?
PT-141 primarily acts as a melanocortin receptor agonist, with highest affinity for the melanocortin 4 receptor (MC4R) and melanocortin 1 receptor (MC1R). Research suggests the following mechanisms:
1. Central Nervous System: PT-141 activates MC4R in specific brain regions, particularly the hypothalamus and brainstem areas involved in sexual response. This activation is thought to influence hypothalamic signalling pathways.
2. Neurotransmitter Modulation: Studies indicate that PT-141 may increase dopamine release in the medial preoptic area, a region crucial for sexual motivation.
3. Peripheral Effects: PT-141's interaction with MC1R on melanocytes has been studied for potential effects on skin pigmentation.
Research
1. Melanocortin Receptor Research:
PT-141 (bremelanotide) is a cyclic heptapeptide analog of α-MSH studied for its activity at the MC3 and MC4 receptors in the central nervous system.
2. Other Areas of Investigation:
Pigmentation: Limited research has examined its activity at the MC1 receptor in melanogenesis models.
Cardiovascular Monitoring: Studies have recorded blood pressure and heart rate as safety measurements.
Handling & Safety
Handle as a laboratory research chemical of unknown hazard. Use gloves and eye protection, avoid inhalation of the lyophilized powder, and follow standard laboratory handling procedures.
Reconstitute and store according to the product label. Lyophilized material should be kept cool, dry and protected from light; reconstituted material should be held at 2-8°C and protected from light.
The safety profile of PT-141 has not been established. This compound is supplied for laboratory research use only and is not approved for human or veterinary use.
Summary
PT-141 (Bremelanotide) is a synthetic peptide melanocortin receptor agonist that has been the subject of extensive research into central melanocortin signalling, including preclinical studies of melanocortin-4 receptor pathways involved in sexual behaviour. Ongoing studies continue to explore its receptor pharmacology, mechanisms of action, and safety profile in research models.
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