Free US shipping for orders above $200

https://images.powerpeptides.com/TB-500_10mg.png
Popular
NEW

TB-500

Product information

$147.99

  • Buy 3+ for $140.59 each and save 5%
  • Buy 5+ for $136.15 each and save 8%
  • Buy 10+ for $133.19 each and save 10%

Size:

TB-500 (10mg)

$ 147.99

Ships Today if ordered within 8 hrs 58 min.

Free FedEx next-day delivery within the US on orders over $200, with a tracking number provided.

Third party tested

FREE Bacteriostatic Water

For every $400 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.

Product description

TB-500, also known as Thymosin Beta-4 (Tβ4), is a naturally occurring peptide that has shown promise in promoting wound healing, reducing inflammation, and stimulating hair growth. TB-500 has been extensively studied for its potential therapeutic applications in various fields, including dermatology, ophthalmology, and regenerative medicine.

Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.

Table of Contents

  1. Characteristics
  2. How does TB-500 work?
  3. Research
  4. Side Effects
  5. Summary
  6. Certificate of Analysis (COA)
  7. References

Characteristics

Molecular Formula

C212H350N56O78S

CAS Number

77591-33-4

Molar Mass

4963.4 g/mol

Amino Acid Sequence

Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

Synonyms

Thymosin Beta-4, Tβ4, TMSB4X, PTMB4, TB500

Solubility

Water-soluble

Organoleptic Profile

White to off-white powder

Composition

Synthetic peptide

How does TB-500 work?

TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide conserved across species and expressed in various tissues. Research has shown that TB-500 interacts with actin, a protein crucial for cell migration and tissue remodeling. This interaction promotes actin polymerization, which is essential for angiogenesis and cell migration to injury sites.

Studies have demonstrated that TB-500 modulates the expression of genes involved in inflammation, wound healing, and tissue regeneration. For instance, it has been found to upregulate matrix metalloproteinases (MMPs), enzymes key to extracellular matrix remodeling and wound healing.

Research

Research in mammalian models has revealed:

  • Wound healing: TB-500 has been shown to enhance keratinocyte and fibroblast migration, stimulate angiogenesis, and reduce inflammation, contributing to faster healing in various wound types.

  • Anti-inflammatory effects: Studies have demonstrated TB-500's ability to reduce pro-inflammatory cytokine production and increase anti-inflammatory cytokine levels in various inflammatory conditions.

  • Hair growth stimulation: Research using mammalian models has found that TB-500 can increase hair follicle size and promote the transition from telogen to anagen phase.

  • Neuroprotection: Studies have explored TB-500's potential to reduce neuroinflammation, oxidative stress, and apoptosis in models of neurological disorders.

  • Cardioprotection: In mammalian models of myocardial infarction, TB-500 has been shown to reduce infarct size, improve cardiac function, and promote angiogenesis.

While these findings are promising, it is important to note that TB-500 is currently a research tool, and its effects in mammals are still being studied.

Side Effects

  • Injection site reactions (pain, redness, swelling)

  • Headache

  • Nausea

  • Dizziness

  • Fatigue

Summary

TB-500, a synthetic version of the naturally occurring peptide Thymosin Beta-4, has shown remarkable potential in various research settings. The peptide has been extensively studied for its ability to promote wound healing, reduce inflammation, stimulate hair growth, provide neuroprotection, and offer cardioprotection. TB-500 exerts its effects through multiple mechanisms, including its interaction with actin, modulation of gene expression, and regulation of inflammatory pathways.

As a research tool, TB-500 offers a valuable opportunity to explore the complex mechanisms underlying wound healing, inflammation, and tissue regeneration. The insights gained from these studies may pave the way for the development of novel therapeutic strategies for a wide range of conditions, from skin wounds and hair loss disorders to neurodegenerative diseases and cardiovascular disorders.

References

  1. Bubb MR. Thymosin beta 4 interactions. Vitam Horm. 2003;66:297-316. doi: 10.1016/s0083-6729(03)01008-2. PMID: 12852258.

  2. Sosne G. Thymosin beta 4 and the eye: the journey from bench to bedside. Expert Opin Biol Ther. 2018 Jul;18(sup1):99-104. doi: 10.1080/14712598.2018.1486818. PMID: 30063853.

  3. Pipes GT, Yang J. Cardioprotection by Thymosin Beta 4. Vitam Horm. 2016;102:209-26. doi: 10.1016/bs.vh.2016.04.004. Epub 2016 May 31. PMID: 27450736.

  4. Kim J, Jung Y. Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells. Vitam Horm. 2016;102:121-49. doi: 10.1016/bs.vh.2016.04.011. Epub 2016 May 31. PMID: 27450733.

  5. Han HJ, Kim S, Kwon J. Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells. Neurotox Res. 2019 Jul;36(1):58-65. doi: 10.1007/s12640-018-9985-0. Epub 2018 Dec 15. PMID: 30552633.

  6. Kim J, Jung Y. Potential role of thymosin Beta 4 in liver fibrosis. Int J Mol Sci. 2015 May 8;16(5):10624-35. doi: 10.3390/ijms160510624. PMID: 26006229; PMCID: PMC4463665.

Why Power Peptides is the best place to buy TB-500

Power Peptides™ is more than just a trusted U.S. supplier of research peptides. We are a catalyst for scientific advancement, dedicated to providing the highest quality peptides that empower our clients to push the boundaries.

Unparalleled Quality

Our proprietary processes and meticulous sourcing of premium materials ensure that every peptide we offer meets the most stringent standards.

Independently Verified

Every product undergoes extensive testing, both in-house and through independent, third-party laboratories.

Fast Shipping & Support

We provide fast and reliable shipping, using the best couriers and high-quality packaging materials to ensure that your peptides arrive promptly and in optimal condition.

More from Immunomodulators

View All