TB-500

TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide conserved across species and expressed in various tissues. Research has shown that TB-500 interacts with actin, a protein crucial for cell migration and tissue remodeling. This interaction promotes actin polymerization, which is essential for angiogenesis and cell migration to injury sites.

Studies have demonstrated that TB-500 modulates the expression of genes involved in inflammation, wound repair, and tissue remodeling. For instance, it has been found to upregulate matrix metalloproteinases (MMPs), enzymes key to extracellular matrix remodeling and wound repair.

Handle as a laboratory research chemical of unknown hazard. Use gloves and eye protection, avoid inhalation of the lyophilized powder, and follow standard laboratory handling procedures.

Reconstitute and store according to the product label. Lyophilized material should be kept cool, dry and protected from light; reconstituted material should be held at 2-8°C and protected from light.

The safety profile of TB-500 has not been established. This compound is supplied for laboratory research use only and is not approved for human or veterinary use.

TB-500, a synthetic version of the naturally occurring peptide Thymosin Beta-4, has been examined in various research settings. The peptide has been studied in models of wound repair, inflammatory signalling, follicle cycling, neuroprotection and cardiac tissue. TB-500 exerts its effects through multiple mechanisms, including its interaction with actin, modulation of gene expression, and regulation of inflammatory pathways.

As a research tool, TB-500 offers a valuable opportunity to explore the complex mechanisms underlying wound repair, inflammation, and tissue remodeling. These studies inform further laboratory investigation across a range of models, from dermal wound and follicle research to neurodegeneration models.